C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/91 (2006.01) A61K 31/195 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) C07C 311/19 (2006.01) C07C 323/58 (2006.01) C07D 209/48 (2006.01) C07D 209/88 (2006.01) C07D 213/56 (2006.01) C07D 333/76 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2256631
The present invention relates to compounds of formula (I) that inhibit matrix metalloproteinases and to a method of inhibiting matrix metalloproteinases using the compounds, wherein Q is an un-natural amino acid. More particularly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal diseases, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthritis, or other autoimmune or inflammatory disases dependent upon tissue invasion by leukocytes.
La présente invention concerne des composés de la formule I inhibant des métalloprotéases matricielles ainsi qu'un procédé d'inhibition de métalloprotéases matricielles en utilisant ces composés; dans la formule (I), Q est un acide aminé non-naturel. Plus précisément, la présente invention concerne un procédé de traitement d'affections impliquant des métalloprotéases matricielles telles que la sclérose en plaques, la rupture de la plaque athéroscléreuse, la resténose, l'anévrisme de l'aorte, l'insuffisance cardiaque, la parodontopathie, l'ulcération cornéenne, les brûlures, les ulcères de décubitus, les lésions ou ulcères chroniques, les métastases cancéreuses, l'angiogenèse tumorale, l'arthrite, ou d'autres affections auto-immunes ou inflammatoires découlant de l'invasion de tissus par des leucocytes.
Picard Joseph Armand
Sliskovic Drago Robert
Macrae & Co.
Warner-Lambert Company
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