Tgf-.beta. antagonist multi-target binding proteins

Details Tgf-.beta. antagonist multi-target binding proteins Tgf-.beta. antagonist multi-target binding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2729810

This disclosure provides a multi-target fusion protein composed of a TGF? antagonist domain and another binding domain antagonistic for a heterologous target (such as IL6, IL10, VEGF, TNF, HGF, TWEAK, IGF) or agonistic for a heterologous target (such as GITR). The multi-specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.

Cette invention concerne une protéine hybride multi-cible constituée dun domaine antagoniste du TGF-b et dun autre domaine de liaison antagoniste dune cible hétérologue (par exemple IL6, IL10, VEGF, TNF, HGF, TWEAK, IGF) ou agoniste dune cible hétérologue (par exemple GITR). La protéine hybride multi-spécifique peut également contenir un domaine interposé séparant les domaines de liaison et permettant la dimérisation. Cette invention concerne aussi des polynucléotides codant les protéines hybrides multi-spécifiques, des compositions constituées des protéines hybrides, et des procédés dutilisation des protéines hybrides multi-spécifiques et des compositions.

Affiliated with

Also associated with

Rating

Tgf-.beta. antagonist multi-target binding proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tgf-.beta. antagonist multi-target binding proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tgf-.beta. antagonist multi-target binding proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1427619