Thiazole derivative

Details Thiazole derivative Thiazole derivative

C - Chemistry, Metallurgy

07

D

C07D 277/82 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 277/46 (2006.01) C07D 277/60 (2006.01) C07D 317/64 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2233611

A thiazole compound of formula (I), wherein T is lower alkylene; u is 0 or 1; R1 and R2 are the same or different and are each H, or lower alkyl, etc.; R3 is (1) or (2); R4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity or protein kinase C(PKC, Ca2+/phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.

L'invention concerne un composé de thiazole de la formule (I) dans laquelle T représente alkylène inférieur; U représente 0 ou 1; R?1¿ et R?2¿ sont identiques ou différents et représentent chacun H ou alkyle inférieur, etc; R?3¿ représente (1) ou (2); R?4¿ représente H ou alcanoyloxy inférieur-alkyle inférieur, pouvant présenter une activité inhibitrice sur la protéine kinase C (PKC, Ca?2+¿/sérine/thréonine protéine phosphatase dépendante des phospholipides), ce composé est utile en tant qu'inhibiteur de protéine kinase C.

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