A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/365 (2006.01) A61K 31/55 (2006.01) A61K 31/635 (2006.01) A61P 7/10 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2407929
Combinations of diuretics and vasopressin antagonists are useful to slow and reverse the symptoms and process of congestive heart failure, to increase the excretion of water in the urine, and to decrease the excretion of sodium and potassium ions in urine. Preferred vasopressin antagonists have the formula (I) wherein R and R5 are hydrogen or lower alkyl; R1, R2, and R3 are hydrogen, halo, alkyl, alkoxy, and amino; and R4 is hydrogen or phenyl, and a pharmaceutically acceptable salt thereof.
L'invention concerne des combinaisons de diurétiques et d'antagonistes de vasopressine servant à ralentir et à inverser les symptômes et le processus d'insuffisance cardiaque congestive, afin d'augmenter l'excrétion d'eau dans l'urine, et de réduire l'excrétion d'ions sodium et d'ions potassium dans l'urine. Les antagonistes de vasopressine préférés sont représentés par la formule dans laquelle R et R?5¿ sont hydrogène ou alkyle inférieur; R?1¿, R?2¿, et R?3¿ sont hydrogène, halo, alkyle, alkoxy, et amino; et R?4¿ est hydrogène ou phényle, et un sel acceptable d'un point de vue pharmaceutique.
Bakker-Arkema Rebecca Guggemos
Pressler Milton Lethan
Sim & Mcburney
Warner-Lambert Company
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