C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/12 (2006.01)
Patent
CA 2534294
The present invention is further directed to compounds of the formulas: (I) (II) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24 and R25 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
La présente invention concerne des composés des formule (I)et (II) (où R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7?, R¿8?, R¿9?, R¿10?, R¿15?, R¿16?, R¿17?, R¿18?, R¿19?, R¿24? et R¿25? ont la définition donnée). Ces composés sont des modulateurs de l'activité du récepteur de la chimiokine et sont utiles dans la prévention ou le traitement de certains troubles et maladies inflammatoires et immunorégulatoires, allergies, états atopiques, y compris la rhinite allergique, la dermatite, la conjonctivite et l'asthme, ainsi que les pathologies autoimmunes telles que l'arthrite rhumatoïde et l'athérosclérose. L'invention concerne également des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies dans lesquelles les récepteurs de la chimiokine sont impliqués.
Butora Gabor
Goble Stephen
Yang Lihu
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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