Human gene critical to fertility

Details Human gene critical to fertility Human gene critical to fertility

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 17/00 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2443341

Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater genomic, cDNA and protein sequences are provided, as are fragments and variants thereof. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using Mater molecules in diagnoses, prognosis, and treatment of infertility and reduced fertility, and kits related to such methods. Also provided are methods for using Mater as a contraceptive agent. The disclosure also describes compounds involved in such methods, and the identification of such compounds.

L'invention concerne des séquences d'acides nucléiques et des séquences protéiques qui sont essentielles pour la fertilité. Plus particulièrement, l'invention concerne des séquences génomiques humaines Mater de protéines et d'ADNc, ainsi que des fragments et des variants de celles-ci. Le gène Mater fonctionnel est nécessaire à la fertilité féminine; les zygotes provenant d'ovocytes nuls Mater ne progressent pas au-delà du stade bicellulaire. L'invention concerner des méthodes permettant d'utiliser des molécules Mater pour diagnostiquer, pronostiquer et traiter l'infertilité et pour réduire l'infertilité. L'invention concerne également des trousses associées à ces méthodes. En outre, cette invention concerne des méthodes permettant d'utiliser le gène Mater en tant qu'agent contraceptif. On décrit également des composés utilisés dans ces méthodes, ainsi que l'identification de ces composés.

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