Mannich base n-oxide drugs

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 19/06 (2006.01) A01N 33/24 (2006.01) A61K 31/5377 (2006.01) A61K 31/7072 (2006.01) A61P 35/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2681222

The invention relates to Mannich base N-oxides of drugs containing acidic N- H groups. Pharmaceutical compositions comprising therapeutically effective amount of Mannich base N-oxides, or a pharmaceutically acceptable salt or prodrug thereof, are disclosed. Further, the invention relates to methods of using the compounds, alone or in combination with one or more other active agents or treatments, are disclosed.

L'invention concerne des N-oxydes de bases de Mannich de médicaments contenant des groupes N-H acides. L'invention concerne également des compositions pharmaceutiques comprenant une dose efficace sur le plan pharmaceutique de N-oxydes de bases de Mannich, ou un sel ou un promédicament acceptable sur le plan pharmaceutique de ceux-ci. L'invention concerne en outre des procédés d'utilisation desdits composés, seuls ou en combinaison avec un ou plusieurs autres agents actifs ou traitements.

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