C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 38/37 (2006.01) A61K 38/46 (2006.01) A61K 38/49 (2006.01) A61K 48/00 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) A61L 33/00 (2006.01) A61L 33/18 (2006.01) C07K 14/635 (2006.01) C07K 14/705 (2006.01) C07K 14/755 (2006.01) C12N 9/38 (2006.01) C12N 9/72 (2006.01) C12N 11/02 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2095153
Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced endothelial cells are disclosed. Such endothelial cells are useful in improving the performance of vascular grafts and in delivering the encoded polypeptide or protein, such as an enzyme, a hormone, a receptor or a drug, to an individual.
Birinyi Louis K.
Callow Allan D.
Cohen Lawrence K.
Mulligan Richard C.
Rafield Lori F.
Brigham & Women's Hospital
Cell Genesys Inc.
Howard Hughes Medical Institute
New England Medical Center Hospitals
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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