Method of producing optically active alcohol

Details Method of producing optically active alcohol Method of producing optically active alcohol

C - Chemistry, Metallurgy

07

C

C07C 29/143 (2006.01) C07B 53/00 (2006.01) C07B 61/00 (2006.01) C07C 33/22 (2006.01) C07C 67/31 (2006.01) C07C 69/65 (2006.01) C07D 205/08 (2006.01) C07D 263/14 (2006.01)

Patent

CA 2642388

A method of stereoselectively producing an optically active alcohol characterized by comprising reducing an aromatic ketone by using an optically active 2-[bis(4-methoxyphenyl)hydroxymethyl]pyrrolidine, sodium borohydride and chlorotrimethylsilane. According to this method, an optically active alcohol showing a high enantioselectivity can be produced even on a large scale.

La présente invention a pour objet une méthode de synthèse stéréosélective d'un alcool optiquement actif caractérisée en ce qu'elle comprend la réduction d'une cétone aromatique par utilisation d'une 2-[bis(4-méthoxyphényl)hydroxyméthyl]pyrrolidine optiquement active, de borohydrure de sodium et de chlorotriméthylsilane. Selon cette méthode, un alcool optiquement actif présentant une énantiosélectivité importante peut être produit, y compris à grande échelle.

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