Sustained releasable parenteral pharmaceutical preparations...

Details Sustained releasable parenteral pharmaceutical preparations... Sustained releasable parenteral pharmaceutical preparations...

A - Human Necessities

61

K

A61K 47/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/70 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 38/28 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2130868

ABSTRACT A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temper- ature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.

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