Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2432223

This invention describes novel pyrazole compounds of formula (I') wherein Q' is -0-, -C(R6')2-, 1,2-cyclopropanediyl, 1,2-cyclobutanediyl, or 1,3- cyclopropanediyl, and R1 is T-Ring D, wherein Ring D is 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently seleted from T-R3 or L-Z-R3, or Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2' are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

La présente invention concerne des composés pyrazoliques représentés par la formule générale (I'). Dans cette formule, Q' est -0-, -C(R?6'¿)¿2?-, 1,2-cyclopropanediyle, 1,2-cyclobutanediyle, ou 1,3-cyclopropanediyle. R?1¿ est le D du cycle T, lui-même fonction monocyclique de 5 à 7 membres ou fonction bicyclique de 8 à 10 membres, appartenant au groupe des aryle, hétéroaryle, hétérocyclyle ou carbocyclyle. R?x¿ et R?y¿ sont choisis indépendamment parmi les T-R?3¿ ou L-Z-R?3¿, mais ils peuvent également être pris ensemble avec leurs atomes intervenant de façon à former un cycle de 5 à 7 membres, fusionné, insaturé ou partiellement insaturé portant de 0 à 3 hétéroatomes. Enfin, R?2¿ et R?2'¿ sont tels que décrits dans la spécification. Ces composés conviennent comme inhibiteurs des protéine linase, plus particulièrement comme inhibiteurs des Aurora-2 et GSK-3, dans le cadre d'un traitement contre le cancer, la diabète et la maladie d'Alzheimer.

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