Transport peptides and uses therefor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 7/06 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2474807

The invention describes isolated transport peptides, which cross the cell membrane of a cell and/or home to a target cell. The invention also describes a transport complex in which a transport peptide is linked to a cargo moiety to be delivered into/to a cell. Methods are disclosed describing delivery of a transport complex into and/or to a cell. Vectors and host cells comprising transport peptides and transport complexes are also described, as well as pharmaceutical compositions including transport complexes of the present invention.

L'invention concerne des peptides de transport isolés qui traversent la membrane cellulaire d'une cellule ou se dirigent vers une cellule cible. L'invention concerne également un complexe de transport dans lequel un peptide de transport est relié à un groupe fonctionnel de cargaison à livrer dans ou à une cellule. L'invention concerne en outre des procédés pour la livraison d'un complexe de transport dans ou à une cellule. L'invention concerne enfin des vecteurs et des cellules hôtes comprenant des peptides de transport et des complexes de transport, ainsi que des compositions pharmaceutiques incluant des complexes de transport selon l'invention.

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