Ophthalmic solution

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61H 35/02 (2006.01) A61L 12/14 (2006.01) C11D 3/00 (2006.01)

Patent

CA 2585760

An improved ophthalmic composition comprising an anionic polymeric substance, such as Hyaluronic Acid and/or Carboxymethylcellulose, in combination with any of various cationic monomeric or dimeric antimicrobial agents, such as Cetylpyridinium Chloride and/or Alexidine Dihydrochloride, wherein said compositions provide additional comfort and biocompatibility with lenses without significantly affecting the antimicrobial efficacy of the antimicrobial agent and without therefore requiring a substantially increased concentration of the agent such as that could expose contact lens wearers to increased levels of the disinfecting agent. Solutions according to the present invention may be used for effective multipurpose contact lens disinfection compositions, lens packaging solution compositions, and/or eye drops such as rewetters and tears.

L'invention concerne une composition ophtalmique améliorée comprenant une substance polymère anionique, telle qu'un acide hyaluronique et/ou une carboxyméthylcellulose, combinée avec des agents antimicrobiens monomères ou dimères cationiques variés quelconques, tels qu'un chlorure de cétylpyridinium et/ou un dihydrochlorure d'alexidine. Lesdites compositions fournissent un confort supplémentaire et une biocompatibilité avec des lentilles sans affecter significativement l'efficacité antimicrobienne et sans requérir une augmentation sensible de concentration de l'agent telle qu'elle pourrait exposer les porteurs de lentilles de contact à des niveaux accrus d'agent désinfectant. Les solutions de l'invention peuvent être utilisées dans des compositions de désinfection de lentilles de contact polyvalentes efficaces, dans des compositions de solution d'emballage de lentilles et/ou dans des gouttes ophtalmiques telles que des agents de réhumidification et des larmes.

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