C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) A61K 31/7088 (2006.01) A61K 31/711 (2006.01) A61K 38/45 (2006.01) C12Q 1/68 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2651758
The present invention relates to novel treatments of mammalian and human heart failure directed at improving cardiac creatine kinase metabolism, the prime energy reserve of cardiac muscle. This also relates to novel treatments using gene transfer vectors to increase myocardial creatine kinase protein expression and/or creatine kinase activity, as well as flux through the creatine kinase reaction and to thereby improve cardiac contractile function and ameliorate remodeling In heart failure. Disclosed herein are methods for screening and identifying compounds that increase creatine kinase expression and/or creatine kinase activity as potential pharmaceutical compositions for heart failure therapy.
La présente invention concerne de nouveaux traitement de l'insuffisance cardiaques chez les mammifères et l'être humain, destinés à améliorer le métabolisme de la créatine kinase cardiaque, la première réserve d'énergie du muscle cardiaque. L'invention concerne également de nouveaux traitements employant des vecteurs de transfert génique pour augmenter l'expression et/ou l'activité de la créatine kinase du myocarde, ainsi que le débit par la réaction de la créatine kinase, et ainsi augmenter la fonction contractile du muscle cardiaque et améliorer la remodelage de l'insuffisance cardiaque. L'invention a également pour objet des procédés pour cribler et identifier des composés qui augmentent l'expression et/ou l'activité de la créatine kinase et des compositions pharmaceutiques potentielles destinées à traiter l'insuffisance cardiaque.
Hunter Champion
Weiss Robert G.
Hunter Champion
Nanocor Therapeutics Inc.
Osler Hoskin & Harcourt Llp
Weiss Robert G.
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