Reovirus for the treatment of lymphoid malignancies

Details Reovirus for the treatment of lymphoid malignancies Reovirus for the treatment of lymphoid malignancies

A - Human Necessities

61

K

A61K 39/15 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2435967

A method of treating a lymphoid malignancy in an animal, comprising administering to cells of the lymphoid malignancy an amount of reovirus sufficient to cause substantial lysis of the cells, is provided. The method is useful for treating a variety of lymphoid malignancies, including but not limited to Burkitt's lymphoma, Hodgkin's lymphoma, chronic lymphocytic leukemia, and non-Hodgkin's lymphomas such as diffuse large B-cell lymphoma, follicular lymphoma, and mantle-cell lymphoma. The invention is further useful for purging tissues of cells of lymphoid malignancies prior to transplantation or reintroduction to an animal.

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