Residual solvent extraction method and microparticles...

A - Human Necessities – 61 – K

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Details

A61K 47/34 (2006.01) A61K 9/16 (2006.01) A61K 38/17 (2006.01) B01J 13/08 (2006.01) B01J 13/12 (2006.01) B01J 13/20 (2006.01)

Patent

CA 2454027

Methods for preparing microparticles having reduced residual solvent levels, Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles, Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post- hardening wash step.

Cette invention concerne des procédés d'obtention de microparticules présentant des niveaux réduits de solvant résiduel. Les microparticules sont mises en contact avec un système de lavage non aqueux destiné à réduire le niveau de solvant résiduel dans les microparticules. Pour les systèmes de lavage non aqueux, on utilise de préférence de l'éthanol à 100 % et un mélange d'éthanol et d'heptane. Un mélange de solvant solvant durcisseur et solvant de lavage peut être utilisé pour durcir et laver les microparticules en une seule opération, ce qui rend superflue une opération de lavage post-durcissement.

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