C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/00 (2006.01) A61K 39/245 (2006.01) C07K 14/045 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2271784
The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The peptides are capable of activating CTLs and CTLp's in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Polypeptide and lipopeptide vaccines, with and without adjuvants, also are disclosed.
La présente invention concerne une pluralité de peptides (et leurs variantes immunologiquement fonctionnelles) constituant des épitopes immunogènes reconnus par les lymphocytes T cytotoxiques CD8?+¿ de classe I à restriction MHC chez les patients couvant une infection latente par le cytomégalovirus (HCMV). Ces peptides, qui sont capables d'activer les CTL et CTLp en absence de réplication virale active, conviennent pour éliciter une réponse immunitaire cellulaire contre le HCMV de la part de sujets normaux et de sujets immunodéficients. L'invention concerne également des vaccins polypeptidiques et lipopeptidiques, avec ou sans adjuvants.
Diamond Don Jeffrey
York Joanne
City Of Hope
Mbm Intellectual Property Law Llp
LandOfFree
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