Process for preparing therapeutic peptide

C - Chemistry – Metallurgy – 07 – K

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C07K 14/435 (2006.01) C07K 14/575 (2006.01) C07K 14/64 (2006.01)

Patent

CA 2744291

This application discloses processes for synthesizing human relaxin Chain B for treatment of diseases mediated by relaxin. This application in particular discloses processes of synthesizing the Chain B of human relaxin using a solid and solution phase ("hybrid") approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to couple the fragments.

La présente demande concerne des procédés de synthèse de la chaîne B de la relaxine humaine pour le traitement de pathologies faisant intervenir la relaxine. La présente demande concerne particulièrement des procédés de synthèse de la chaîne B de la relaxine humaine utilisant une approche « hybride », en phase solide et en solution. Généralement, cette approche inclut la synthèse de trois fragments intermédiaires peptidiques différents par chimie en phase solide. La chimie en solution est ensuite employée pour coupler les fragments.

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