Method of inducing immune tolerance

Details Method of inducing immune tolerance Method of inducing immune tolerance

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2535583

Methods for inducing tolerance to a transplant in a subject are disclosed. The methods comprise administering multiple doses of a therapeutically effective amount of a CD40 antagonist alone or in combination with a CD86 antagonist, wherein the first dose of the antagonist is given before or at the time of transplantation; and administering multiple doses of a therapeutically effective amount of an immunosuppressive drug, wherein the first dose of the immunosuppressive drug is given at least several days after transplantation.

L'invention concerne des méthodes permettant d'induire une tolérance à un greffon chez un sujet. Ces méthodes consistent à administrer plusieurs doses thérapeutiques d'un antagoniste CD40 seul ou combiné à un antagoniste CD86, la première dose d'antagoniste étant administrée avant ou pendant la transplantation ; et à administrer plusieurs doses thérapeutiques d'un médicament immunosuppresseur, la première dose de médicament immunosuppresseur étant administrée au moins plusieurs jours après la transplantation.

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