Methods of treating type i hypersensitivity using...

Details Methods of treating type i hypersensitivity using... Methods of treating type i hypersensitivity using...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 35/74 (2006.01) A61K 38/17 (2006.01) A61K 39/35 (2006.01)

Patent

CA 2252604

Methods and compositions for treating type I immunoglobin E (IgE)-dependent hypersensitivity by the administration of monophosphoryl lipid A(MLA) or 3-deacylated monophosphoryl lipid A (3D-MLA) are disclosed. MLA or 3D-MLA administered alone or in combination with an allergen to a patient suffering from type I hypersensitivity reduces levels of total or allergen specific IgE and increases levels of IgG antibody in that patient. MLA and 3D-MLA can be administered as part of a desensitization regimen or as a component of a prophylactic vaccine to prevent a type I hypersensitivity reaction.

Procédés et compositions destinés au traitement de l'hypersensibilité dépendante de l'immunoglobuline E (IgE) de type I par administration du lipide monophosphoryle A (MLA) ou du lipide monophosphoryle A 3-désacylé (3D-MLA). Le MLA ou le MLA-3D, administré seul ou en association avec un allergène à un patient souffrant de l'hypersensibilité de type I, réduit les niveaux d'IgE total ou spécifique de l'allergène et augmente les niveaux des anticorps dirigés contre l'IgG chez ce patient. Le MLA et le MLA-3D peuvent être administrés dans le cadre d'une posologie de désensibilisation ou comme un constituant d'un vaccin prophylactique pour prévenir une réaction d'hypersensibilité de type I.

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