Piperidine derivatives as neurokinin 1 antagonists

Details Piperidine derivatives as neurokinin 1 antagonists Piperidine derivatives as neurokinin 1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/451 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 29/00 (2006.01) C07D 211/16 (2006.01) C07D 211/58 (2006.01) C07D 401/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2435946

The invention relates to compounds of the general formula, wherein R1 is optionally substituted phenyl, morpholinyl, piperazinyl, pyrrolidinyl, piperidinyl or is thiomorpholinyl, 1-oxo-thiomorpholinyl or 1,1- dioxothiomorpholinyl. These compounds have a good affinity to the NK-1 receptor and they are therefore suitable in the control or treatment of diseases, related to this receptor.

L'invention se rapporte à des composés représentés par la formule générale (I), dans laquelle R?1¿ est phényle éventuellement substitué, morpholinyle, pipérazinyle, pyrrolidinyle, pipéridinyle ou est thiomorpholinyle, 1-oxo-thiomorpholinyle ou 1,1-dioxothiomorpholinyle. Ces composés présentent une bonne affinité pour le récepteur NK-1 et ils s'avèrent par conséquent adaptés au contrôle ou au traitement de maladies associées à ce récepteur.

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