Method for producing 2-halogen-pyridine-carboxylic acid amides

Details Method for producing 2-halogen-pyridine-carboxylic acid amides Method for producing 2-halogen-pyridine-carboxylic acid amides

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2463625

The invention concerns a method for producing 2-halogen-pyridine-carboxylic acid amides of primary aromatic monoamines I which include, in ortho position relative to the amino group, a different hydrogen substituent, by reacting 2- halogen-pyridine-carboxylic acid chloride II with the aromatic monoamine I. The inventive method is characterized in that it consists in carrying out the reaction in a solvent mixture consisting of at least an organic solvent non- miscible with water, the mixture containing or not containing less than 10 mole %, relative to the 2-halogen-pyridine-carboxylic acid chloride II, a base different from I and II.

L'invention concerne un procédé pour la production d'amides d'acide 2-halogène-pyridine-carboxylique de monoamines aromatiques primaires I qui présentent, dans la position ortho par rapport au groupe amino, un substituant différent de l'hydrogène, par réaction de chlorure d'acide 2-halogène-pyridine-carboxylique II avec le monoamine aromatique I. Le procédé selon l'invention est caractérisé en ce qu'on effectue la réaction dans un mélange de solvant constitué d'eau et d'au moins un solvant organique non miscible avec l'eau, le mélange ne contenant pas ou contenant moins de 10 mole %, par rapport au chlorure d'acide 2-halogène-pyridine-carboxylique II, d'une base différente de I et de II.

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