Receptor expression cells and use thereof

Details Receptor expression cells and use thereof Receptor expression cells and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/09 (2006.01) C07K 7/23 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2147344

RECEPTOR EXPRESSION CELLS AND USE THEREOF ABSTRACT OF THE DISCLOSURE Disclosed are CHO cells which are capable of continuous production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.

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