A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2586840
The present invention relates to a method of reversing left ventricle remodeling by combined administration of therapeutically effective amounts ranolazine and at least one co-remodeling agent, which may be an ACE inhibitor, an ARB, or a beta-blocker. The method finds utility in the treatment of heart failure. This invention also relates to pharmaceutical formulations that are suitable for such combined administration.
La présente invention concerne un procédé pour inverser un remodelage du ventricule gauche par administration combinée de quantités thérapeutiques efficaces de ranolazine et d'au moins un agent de co-remodelage pouvant être un inhibiteur de l'enzyme de conversion de l'angiotensine, un bloqueur des récepteurs de l'angiotensine II ou un bêtabloquant. Ce procédé peut être utilisé pour traiter l'insuffisance cardiaque. L'invention concerne également des formulations pharmaceutiques adaptées à cette administration combinée.
Blackburn Brent
Sabbah Hani
Cv Therapeutics Inc.
Gilead Palo Alto Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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