Mhc oligomer and method of making the same

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2596953

The invention discloses MHC oligomers and methods for making the same comprising at least two functional MHC complexes having a peptide binding groove, each MHC complex having a peptide bound in the peptide binding groove of the MHC complex, wherein each peptide has a modification which allows highly specific oligomerisation of the functional MHC complexes through a core structure.

La présente invention concerne des oligomères MHC et des procédés de fabrication de ceux-ci, comprenant au moins deux complexes MHC fonctionnels ayant un sillon de liaison aux peptides, chaque complexe MHC ayant un peptide lié dans le sillon de liaison aux peptides du complexe MHC, chaque peptide ayant une modification qui permet une oligomérisation hautement spécifique des complexes MHC fonctionnels grâce à une structure de cAEur.

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