Nucleic acid and corresponding protein entitled 193p1e1b...

Details Nucleic acid and corresponding protein entitled 193p1e1b... Nucleic acid and corresponding protein entitled 193p1e1b...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C12N 5/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2469161

A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization.

L'invention concerne un nouveau gène 0193P1E1B (également appelé 193P1E1B) et sa protéine codée, ainsi que des variants de celle-ci. 193P1E1B fait preuve d'une expression tissulaire spécifique dans un tissu adulte normal, et est exprimé de façon aberrante dans les cancers répertoriés dans le Tableau I. En conséquence, 193P1E1B permet d'obtenir une cible diagnostique, pronostique, prophylactique et/ou thérapeutique pour le cancer. Le gène 193P1E1B ou un fragment de celui-ci, ou sa protéine codée, ou des variants de celle-ci, ou un fragment de celle-ci peuvent être utilisés pour induire une réponse immunitaire humorale ou cellulaire. Des anticorps ou des lymphocytes T réagissant avec 193P1E1B peuvent être utilisés pour une immunisation active ou passive.

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