Methods for screening monoclonal antibodies for therapeutic use

Details Methods for screening monoclonal antibodies for therapeutic use Methods for screening monoclonal antibodies for therapeutic use

G - Physics

01

N

167/101, 167/129

G01N 33/577 (2006.01) A61K 39/44 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2016830

ABSTRACT The present invention provides a method for selecting from among many monoclonal antibodies capable of binding to a surface antigen on 2 tumor cell, the antibody which also can internalize into the cell and exert an appropriate molecular effect on the level of gene regulation in the tumor cell. Such antibodies can most effectively be employed to damage the tumor cell.

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