Novel esculetin derivatives and pharmaceutical composition

Details Novel esculetin derivatives and pharmaceutical composition Novel esculetin derivatives and pharmaceutical composition

C - Chemistry, Metallurgy

07

D

C07D 311/18 (2006.01) A61K 31/37 (2006.01) C07D 311/16 (2006.01)

Patent

CA 2116617

A pharmaceutical composition comprising a compound of the general formula (I): (see formula I) wherein R1 and R2 are, independently, a hydrogen atom, a saturated or unsaturated aliphatic acyl having 2 to 25 carbon atoms or benzoyl group and R3 is a hydrogen atom or alkyl group, and a pharmaceutically acceptable carrier is disclosed. Further, a novel compound of the general formula (I) wherein R1 and R2 are, independently, a hydrogen atom, pivaloyl, capryloyl, lauroyl, palmitoyl, stearoyl, linoleoyl, docosahexaenoyl, or benzoyl group, and R3 is a hydrogen atom or methyl group, is also disclosed. The pharmaceutical composition is useful as a chondroprotective agent for prohibiting the destruction of,articular cartilage.

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