Piperidine alcohols

Details Piperidine alcohols Piperidine alcohols

C - Chemistry, Metallurgy

07

D

C07D 211/18 (2006.01) A61K 31/445 (2006.01) A61K 31/4523 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) C07D 211/22 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2382295

The invention relates to compounds of formula (I), wherein R1, R2 and A have the meanings given in claim 1, are potent 5-HT2A antagonists and are suitable for treating psychoses, schizophrenia, depression, neurological disorders, impaired memory, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders such as bulimia and anorexia nervosa, Pre-Menstrual Syndrome and/or for positively influencing obsessive-compulsive disorders, (OCD).

Composés de formule (I) dans laquelle R?1¿, R?2¿ et A possèdent la signification figurant dans la revendication 1, qui sont des antagonistes puissants de 5-HT¿2A? et sont adaptés pour traiter les psychoses, la schizophrénie, la dépression, les troubles neurologiques, les troubles de la mémoire, la maladie de Parkinson, la sclérose latérale amyotrophique, la maladie d'Alzheimer, la chorée de Huntington, les troubles de l'alimentation tels que la boulimie et l'anorexie mentale, le syndrome prémenstruel et/ou pour influencer de manière positive les troubles obsessionnels compulsifs (TOC).

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