Treatment of inner ear hair cells

A - Human Necessities – 61 – K

Patent

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A61K 38/30 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2268331

Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

L'invention porte sur des compositions, procédés et dispositifs favorisant ou renforçant la croissance, la prolifération ou la régénération des tissus de l'oreille interne et en particulier des poils auditifs de l'oreille interne. L'invention porte également sur des compositions et procédés de prophylaxie et de traitement des mammifères affligés de troubles de l'oreille interne ou d'états liés en particulier à des défauts d'audition dus à des lésions desdits poils ou à leur perte ou leur dégénérescence, par administration d'une dose à effet thérapeutique d'IGF-1, ou de FGF-2, ou de leurs agonistes, seuls ou combinés.

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