Peripherally active anti-hyperalgesic opiates

Details Peripherally active anti-hyperalgesic opiates Peripherally active anti-hyperalgesic opiates

A - Human Necessities

61

K

A61K 31/4465 (2006.01) A61K 31/439 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/33 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2356097

Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit substantial central nervous system effects. The anti-diarrheal compound 4-(p-chlorophenyl)- 4-hydrouy-N-N-dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions and methods.

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