C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/54 (2006.01) A61K 31/427 (2006.01) A61P 35/00 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2394538
Compounds of formula (I) and pharmaceutically acceptable salts thereof. As used in formula (I), and throughout the specification, the symbols have the following meanings: R1 and R2 are independently hydrogen, fluorine or alkyl; R3 is aryl or heteroaryl, R4 has various meanings; R5 is hydrogen or alkyl; m is an integer of 0 to 2; and n is an integer of 1 to 3. The compounds of formula (I) are protein kinase inhibitors and are useful in the treatment and prevention of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of neurodegenerative diseases such as Alzheimer's diseases cardiovascular diseases, viral diseases and fungal diseases.
L'invention concerne des composés de la formule générale (I) et des sels pharmaceutiquement acceptables de ces composés, dans lesquelles R¿1? et R¿2? représentent indépendamment un hydrogène, un fluor ou un alkyle, R¿3? représente un aryle ou un hétéroaryle, R¿4? a plusieurs significations, R¿5? représente un hydrogène ou un alkyle, m représente un nombre entier compris entre 0 et 2, et n représente un nombre entier compris entre 1 et 3. Les composés de la formule générale (I) sont des inhibiteurs de la protéine kinase et sont utiles dans le traitement et la prévention de maladies prolifératives comme le cancer, les inflammations et l'arthrite. Ces composés peuvent également s'avérer utiles dans le traitement de maladies neurodégénératives comme les maladies d'Alzheimer, les maladies cardio-vasculaires, les infections virales et les mycoses.
Cai Zhen-Wei
Han Wen-Ching
Hunt John T.
Kim Kyoung S.
Kimball S. David
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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