Topical pharmaceutical composition

Details Topical pharmaceutical composition Topical pharmaceutical composition

A - Human Necessities

61

K

167/226, 167/244

A61K 31/35 (2006.01) A61K 31/41 (2006.01) A61K 47/00 (2006.01) A61K 47/06 (2006.01)

Patent

CA 1085298

A TOPICAL PHARMACEUTICAL COMPOSITION ABSTRACT There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, Image I in which R1 represents hydrogen, hydroxy or -NR5R6, in which R5 and R6, which may be the same or different, each represent hydrogen or alkyl C 1 to 6, an adjacent pair of R2, R3 and R4 form a -(CH2)4- chain, and the remaining substituent R2 or R4 represents alkyl C 1 to 9, E represents a 5-(IH)tetrazolyl- or a -COOH group, and X represents oxygen or a group -NR7- in which R7 may be hydrogen or alkyl C 1 to 6, or a pharmaceutically acceptable derivative thereof. There is also described a method for the treatment of conditions (in man and other animals) which involve skin mast cells and/or delayed (cellular) hypersensitivity reactions, which comprises administering a compound of formula I, or a pharmaceutically acceptable derivative thereof to a subject suffering from such a condition.

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