Endothelial cell specifically binding peptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 38/08 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 14/005 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12N 15/33 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2511665

The present invention relates to peptides that specifically bind to endothelial cells. The peptides can be incorporated into gene delivery vector particles and can also direct therapeutic agents, including proteins such as growth factors and cytokines as well as small molecules. The vector particles, peptides, or small molecules can be used for the treatment of cancer and cardiovascular diseases such as ischemic heart disease, peripheral limb disease, vein graft stenosis and restenosis.

L'invention concerne des peptides se liant de façon spécifique à des cellules endothéliales. Ces peptides peuvent être incorporés dans des particules de vecteurs de transport de chaîne et peut également administrer des agents thérapeutiques, notamment des protéines telles que des facteurs de croissance et des cytokines, ainsi que de petites molécules. Les particules de vecteur, les peptides ou les petites molécules peuvent être utilisées dans le traitement du cancer et de maladies cardiovasculaires telles que la cardiopathie ischémique, la maladie des membres inférieurs, la sténose et la resténose de greffons veineux.

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