A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/00 (2006.01) A61K 31/70 (2006.01) G01N 33/00 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2578683
The invention includes a transgenic, non-human mammal useful for identifying candidate compounds for treating neurological and/or psychiatric disorders. Incorporated into the genome of the transgenic mammal is a transgene comprising a glutamate transporter promoter operatively linked to a reporter gene. The transgenic non-human mammal and cells isolated therefrom can be used as an in vivo model for the identification of candidate compounds useful for the treatment of neurological and/or psychiatric disorders.
L'invention concerne un mammifère non-humain, transgénique, utilisé pour l'identification de composés candidats destinés au traitement de troubles neurologiques et/ou psychiatriques. Un transgène comprenant un promoteur de transport de glutamate lié de façon coopérante à un gène rapporteur, est incorporé dans le génome du mammifère transgénique. Le mammifère non-humain, transgénique et des cellules isolées de celui-ci peuvent être utilisés comme modèle in vivo pour l'identification de composés candidats utilisés pour le traitement de troubles neurologiques et/ou psychiatriques.
Regan Melissa
Rothstein Jeffrey D.
Toan Shuy Vang
Johns Hopkins University
Mccarthy Tetrault Llp
LandOfFree
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