Therapy of estrogen-associated disorders

A - Human Necessities – 61 – K

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A61K 31/35 (2006.01) A61K 35/78 (1995.01)

Patent

CA 2325631

A method for the treatment, prophylaxis, amelioration or prevention of disorders associated with abnormally high activity of steroidal estrogens, which includes administering to a human subject a composition comprising an isoflavone-containing extract of clover or chick peas, said extract comprising primarily biochanin, or a ratio of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein in the range of from about 2:1 to about 5:1, optionally in association with one or more pharmaceutically acceptable carriers, excipients, auxiliaries and/or diluents is described. Also described are compositions and uses comprising the isoflavone containing extracts.

On décrit un procédé de traitement, de prophylaxie, d'amélioration ou de prévention de troubles associés à une activité anormalement importante des oestrogènes stéroïdiens, qui consiste à administrer à un individu une composition comprenant un extrait de trèfle ou de pois chiches contenant de l'isoflavone, ledit extrait contenant principalement de la biochanine, ou un taux de biochanine et d'une ou plusieurs des isoflavones appartenant au groupe comprenant la formononétine, la daidzéine et la génistéine situé dans la plage comprise entre environ 2:1 et environ 5:1, facultativement en association avec un ou plusieurs supports, excipients, agents auxiliaires et/ou diluants pharmaceutiquement acceptables. On décrit également des compositions contenant les extraits contenant de l'isoflavone et des procédés d'utilisation de ces derniers.

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