C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/48 (2006.01) A61K 31/40 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2328211
The invention provides compounds which are potent inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to compounds having a structure according to Formula (I): wherein R1, R2, X, Z, m, and n, are defined below. This invention also includes optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically- acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of diseases and conditions which are characterized by unwanted metalloprotease activity. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for metalloprotease-related maladies using these compounds or the pharmaceutical compositions containing them.
L'invention concerne des composés qui sont de puissants inhibiteurs de métalloprotéases et qui sont efficaces dans le traitement de pathologies caractérisées par une activité excessive de ces enzymes. L'invention concerne plus particulièrement des composés ayant une structure de formule (I), dans laquelle R¿1?, R¿2?, X, Z, m et n sont tels que définis ci-dessus. L'invention concerne en outre des isomères optiques, diastéréomères et des énantiomères de formule (I) et leurs sels pharmaceutiquement acceptables, leurs amides biohydrolysables, leurs esters et leurs imides. Les composés de cette invention sont utiles dans le traitement de maladies et de pathologies qui sont caractérisées par une activité indésirable de la métalloprotéase. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés. L'invention concerne en outre de procédés de traitement de maladies liées aux métalloprotéases utilisant ces composés ou les composés pharmaceutiques les contenant.
Almstead Neil Gregory
Cheng Menyan
De Biswanath
Natchus Michael George
Pikul Stanislaw
Kirby Eades Gale Baker
The Procter & Gamble Company
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