Quinazolin-oxime derivatives as hsp90 inhibitors

Details Quinazolin-oxime derivatives as hsp90 inhibitors Quinazolin-oxime derivatives as hsp90 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/84 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 403/10 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2687283

Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.

La présente invention concerne les composés de formule générale (I), ou des stéréoisomères, tautomères, sels pharmaceutiquement acceptables ou prodrogues de ceux-ci, où R1, R2, R3, R4, R5, R6, R8 et R9 sont comme définis dans la présente, sont utiles pour le traitement de maladies et de conditions causées par une activité excessive ou inappropriée des Hsp90 telles que les cancers, les infections virales et les maladies et conditions inflammatoires.

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