Therapeutic isoquinoline compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/02 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 5/00 (2006.01) A61P 25/00 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 217/04 (2006.01) C07D 217/06 (2006.01) C07D 217/12 (2006.01) C07D 217/24 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2464342

Provided herein is a compound of the formula (I), wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

La présente invention se rapporte à un composé représenté par la formule (I), qui s'avère être un composé permettant de traiter des troubles psychiatriques et notamment, mais pas exclusivement, la dépression, l'anxiété généralisée, les troubles de l'alimentation, la démence, les troubles paniques et les troubles du sommeil. Ces composés peuvent également s'avérer utiles pour le traitement des troubles gastro-intestinaux, de la régulation cardio-vasculaire, des troubles moteurs, des troubles endocriniens, des spasmes vasculaires et des dysfonctionnements sexuels. Ces composés sont des antagonistes des récepteurs 5HT¿1B? et 5HT¿1D?.

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