Quinoline derivatives

Details Quinoline derivatives Quinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/24 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) C07D 215/16 (2006.01) C07D 215/26 (2006.01) C07D 215/28 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2658793

The invention relates to new quinoline derivatives which are active CLK-1 inhibitors. More specifically, the CLK-1 inhibitors of the invention are compounds of formula (A). The invention also relates to pharmaceutical compositions comprising such compounds and to methods for the prophylaxis and/or treatment of disorders or their associated symptoms for which the inhibition of CLK-1 is beneficial.

L'invention concerne de nouveaux dérivés de quinoline constituant des inhibiteurs actifs de CLK-1. Les inhibiteurs de CLK-1 de l'invention sont, plus spécifiquement, des composés représentés par la formule (A). L'invention concerne également des compositions pharmaceutiques contenant lesdits composés et des méthodes prophylactiques et/ou thérapeutiques de troubles ou des symptômes associés dans lesquels l'inhibition de CLK-1 est bénéfique.

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