Super-active porcine growth hormone releasing hormone analog

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/25 (2006.01) A61P 3/00 (2006.01) A61P 17/02 (2006.01) A61P 31/18 (2006.01) C07K 14/60 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2378943

Inadequate growth due to deficiencies in growth hormone (GR), growth hormone releasing hormone (GHRH), or genetic diseases can be ameliorated utilizing recombinant protein therapy with a novel GHRH analog having a sequence of (SEQ ID NO:1). Also included is (1) a method of treating growth hormone-related deficiencies associated with the growth hormone pathway; (2) a method for treating growth hormone-related deficiencies associated with genetic disease; (3) a method to improve growth performance in an animal; (4) a method of treating an animal having a growth deficiency disease; (5) a method of increasing the efficiency of an animal used for food; and (6) a method to enhance growth in an animal.

On peut remédier à une croissance inadéquate due à des déficits en hormone de croissance (GR), en somatostatine (GHRH) ou à des maladies génétiques, en utilisant une thérapie par protéines de recombinaison, conjointement avec un analogue de GHRH, présentant une séquence (N· ID SEQ :1). L'invention porte également sur : (1) un procédé de traitement de déficits relatifs à l'hormone de croissance, associés à la voie de l'hormone de croissance ; (2) un procédé de traitement de déficits relatifs à l'hormone de croissance, associés à une maladie génétique ; (3) un procédé pour améliorer les performances de croissance chez un animal ; (4) un procédé de traitement d'un animal souffrant d'une maladie induisant une croissance déficiente ; (5) un procédé d'augmentation du rendement d'un animal utilisé pour l'alimentation ; et (6) un procédé pour augmenter la croissance chez un animal.

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