Use of antagonists of oxytocin and/or vasopressin

Details Use of antagonists of oxytocin and/or vasopressin Use of antagonists of oxytocin and/or vasopressin

A - Human Necessities

61

K

A61K 38/12 (2006.01) A61K 31/4045 (2006.01) A61K 31/438 (2006.01) A61K 31/495 (2006.01) A61K 31/501 (2006.01) A61K 31/5355 (2006.01) A61K 31/536 (2006.01) A61K 38/06 (2006.01) A61K 38/11 (2006.01) A61K 45/06 (2006.01) A61P 15/06 (2006.01)

Patent

CA 2605923

The present invention relates to the use of antagonists of oxytocin, antagonists of oxytocin and vasopressin or antagonists of vasopressin, or their pharmaceutically accepted salts, or their combinations with other drugs for the manufacture of a medicament which main profile of action is inhibition of oxytocin and/or vasopressin receptors in non-pregnant uterus of mammals, that results in improvement of uterine receptivity in embryo transfer. It further relates to the application of these substances for the manufacture of a medicament for regulating the uterine contractile activity in cases of artificial insemination.

L'invention concerne l'utilisation d'antagonistes de l'oxytocine, d'antagonistes de l'oxytocine et de la vasopressine ou d'antagonistes de la vasopressine, des sels pharmaceutiquement acceptables de ceux-ci ou leurs combinaisons avec d'autres médicaments pour la fabrication d'un médicament dont le principal profil d'action est l'inhibition des récepteurs de l'oxytocine et/ou de la vasopressine dans l'utérus non gestant de mammifères, utilisation permettant d'améliorer la réceptivité de l'utérus au transfert d'embryon. L'invention porte également sur l'application de ces substances pour la fabrication d'un médicament de régulation de l'activité contractile utérine en cas d'insémination artificielle.

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