In vitro angiogenesis assay

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/08 (2006.01) C12M 3/00 (2006.01) C12N 5/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2184705

The present invention relates to methods for determining angiogenesis comprising culturing a blood vessel fragment in a physiological gel. In addition the invention provides a method for testing substances for their ability to modulate angiogenesis and a method of determining whether an angiogenic entity such as a tumour will be responsive to anti-englogenic therapy.

Procédés de détermination de l'angiogenèse qui consiste à cultiver un fragment de vaisseau sanguin dans un gel physiologique. En outre, la présente invention concerne un procédé permettant d'analyser la capacité de certaines substances à moduler l'angiogenèse, et un procédé permettant de déterminer si une entité angiogénique telle qu'une tumeur réagira à une thérapie anti-angiogénique.

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