A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 31/045 (2006.01) A61K 31/12 (2006.01) A61K 31/122 (2006.01) A61K 31/125 (2006.01) A61K 31/138 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2225647
A method of regulating the assembly of the protein tau in the brain of a mammal in need of such treatment comprising the step of administering to said mammal a pharmacologically effective amount of a fatty acid liberation or release inhibitor. Also provided is a method of inhibiting production of Alzheimer-type amyloidosis in a mammal comprising the step of administering to said mammal in need of such treatment an effective amount of at least one modulator of fatty acid liberation or release, said modulator capable of controlling the rate of assembly of proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques. In another enbodiment of the present invention, there is provided a method of stimulating polymerization of a tau protein, comprising the step of contacting said protein with a fatty acid. In an other embodiment of the present invention, there is provided a method of stimulating polymerization of an amyloid peptide, comprising the step of contacting said peptide with a fatty acid.
Procédé qui permet de réguler l'assemblage de la protéine tau dans le cerveau d'un mammifère nécessitant ce type de traitement et qui consiste à lui administrer une dose efficace sur le plan pharmacologique d'un inhibiteur de libération ou de relargage d'acides gras. L'invention comprend également un procédé permettant d'inhiber la production d'amylose de type Alzheimer chez un mammifère nécessitant ce type de traitement, qui consiste à lui administrer une dose efficace d'au moins un modulateur de libération ou de relargage d'acides gras. Ledit modulateur étant apte à réguler la vitesse d'assemblage des protéines présentes dans les enchevêtrements neurofibrillaires intracellulaires et dans les plaques amyloïdes extracellulaires. Un autre mode de réalisation de l'invention comprend un procédé qui permet de stimuler la polymérisation d'une protéine tau par la mise de ladite protéine en contact avec un acide gras. Un autre mode de réalisation de l'invention comprend un procédé qui permet de stimuler la polymérisation d'un peptide amyloïde, qui consiste à mettre ledit peptide en contact avec un acide gras.
Binder Lester I.
Wilson David M.
Borden Ladner Gervais Llp
The University Of Alabama At Birmingham Research Foundation
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