Tenidap as an inhibitor of the release of elastage by...

Details Tenidap as an inhibitor of the release of elastage by... Tenidap as an inhibitor of the release of elastage by...

A - Human Necessities

61

K

167/240

A61K 31/40 (2006.01)

Patent

CA 2038410

PC7756GCB TENIDAP AS AN INHIBITOR OF THE RELEASE OF ELASTASE BY NEUTROPHILS Abstract This invention relates to the use of tenidap, 5-chloro-2,3-dihydro-2-oxo-3-(2-thienylcarbonyl)- indole-1-carboxamide, and the pharmaceutically- acceptable base salts thereof to inhibit the release of elastase by neutrophils in a mammal. This invention also relates to the use of tenidap and its salts for treating elastase-mediated diseases and dysfunctions such as arteritis, proteinuria and pulmonary emphysema in mammals. The methods of this invention comprise administering an effective amount of tenidap or salts thereof to a mammal.

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