Methods of producing hybrid g protein-coupled receptors

Details Methods of producing hybrid g protein-coupled receptors Methods of producing hybrid g protein-coupled receptors

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/705 (2006.01) C12N 1/19 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2074837

Methods are disclosed for producing hybrid G protein-coupled receptors. DNA sequences encoding hybrid G protein-cou- pled receptors are provided, wherein the receptors comprise mammalian G protein-coupled receptors having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor, DNA con- structs comprising the following operatively linked elements: a transcriptional promoter, a DNA sequence encoding a hybrid G protein-coupled receptor, wherein the receptor comprises a mammalian G protein- coupled receptor having at least one domain other than the ligand-binding domain replaced with a corresponding domain of a yeast G protein-coupled receptor, and a tran- scriptional terminator. Host cells transformed with the DNA constructs and methods utilizing the transformed cells are also pro- vided.

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