Process for cross-linking collagenous materials and...

Details Process for cross-linking collagenous materials and... Process for cross-linking collagenous materials and...

C - Chemistry, Metallurgy

07

K

204/91.11

C07K 1/00 (2006.01) A61L 27/36 (2006.01) B01J 19/08 (2006.01) C08H 1/06 (2006.01)

Patent

CA 2022480

The present invention relates to a process for cross-linking a proteinaceous material. The process comprises: i) soaking the material to be cross-linked in an aqueous solution of high osmolality; ii) incubating the material in an aqueous buffer including an amount of a photooxidative catalyst sufficient to catalyze photooxidation of the material; and iii) irradiating the material and the catalyst of step (i) with light that includes a range of wavelengths selectively absorbed by the catalyst. Irradiation is effected under conditions such that cross-linking of the material occurs. In a further embodiment, the present invention relates to a cross-linked product produced by the above-described method.

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