C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/775 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61P 3/00 (2006.01) A61P 9/10 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C12N 9/16 (2006.01)
Patent
CA 2645245
Reverse peptides and mimetics of a mammalian serum amyloid A isoform 2.1 (SAA2.1) domain or a portion thereof and compositions and pharmaceutical compositions thereof are provided that enhance the effect on macrophage cholesterol ester hydrolase activity. Methods of using these reverse peptides, mimetics thereof and compositions in the treatment and/or prevention of atherosclerosis as well as coronary heart disease and cardiovascular disease are also provided.
L'invention porte sur des peptides inverses et leurs mimétiques d'un domaine de l'isoforme A de la protéine amyloïde sérique mammalienne 2.1 (SAA2.1) ou une partie de celle-ci, ses compositions et compositions pharmaceutiques qui permettent de renforcer l'effet sur l'activité de la cholestérol ester hydrolase des macrophages. L'invention concerne des procédés d'utilisation de ces peptides inverses, de leurs mimétiques et compositions dans le traitement et/ou la prévention de l'athérosclérose, de la maladie coronarienne et de la maladie cardio-vasculaire.
Queen's University At Kingston
Steeg Carol Miernicki
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