C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 1/00 (2006.01) A61K 31/565 (2006.01)
Patent
CA 2148373
2148373 9506472 PCTABS00036 A method for promoting weight control by treating a subject with a therapeutic amount of one of the .DELTA.5-androstenes listed below to stimulate weight control without affecting appetite or inducing the synthesis of sex hormones. .DELTA.5-Androstenes providing the desired biological activities include: (1) .DELTA.5-Androstene-3.beta.,7.alpha.-diol-17-one, (2) .DELTA.5-Androstene-3.beta.-ol-7,17-dione, (3) .DELTA.5-Androstene-3.beta.,7.alpha.,17.beta.-triol, (4) .DELTA.5-Androstene-3.beta.,17.beta.-diol-7-one, (5) .DELTA.5-Androstene-3.beta.-acetoxy-7,16,17-trione, (6) .DELTA.5-Androstene-3.beta.,16.alpha.-dihydroxy-7,17-dione, (7) .DELTA.5-Androstene-3.beta.-propionoxy-16.beta.-acetoxy-7,17-dione, (8) .DELTA.5-Androstene-3.beta.,7.alpha.,17.beta.-triol-16-one, (9) .DELTA.5-Androstene-3.beta.,17.beta.-diol-7,16-dione, (10) .DELTA.5-Androstene-3.beta.,16.alpha.,17.beta.-triol-7-one and derivatives thereof wherein one or more of the hydroxyl or keto substituents is a group convertible thereto by hydrolysis.
Procédé destiné à favoriser le maintien ou la perte de poids consistant à traiter un sujet à l'aide d'une dose thérapeutique de l'un des DELTA 5-androstènes énumérés ci-dessous de manière que ledit sujet maintienne son poids ou perde du poids sans que cela affecte son appétit ou que cela induise la synthèse d'hormones sexuelles. Les DELTA 5-androstènes entraînant les activités biologiques voulues sont: (1) DELTA 5-androstène-3 beta ,7 alpha -diol-17-one, (2) DELTA 5-androstène-3 beta -ol-7,17-dione, (3) DELTA 5-androstène-3 beta ,7 alpha ,17 beta -triol, (4) DELTA 5-androstène-3 beta ,17 beta -diol-7-one, (5) DELTA 5-androstène-3 beta -acétoxy-7,16,17-trione, (6) DELTA 5-androstène-3 beta ,16 alpha -dihydroxy-7,17-dione, (7) DELTA 5-androstène-3 beta -propionoxy-16 beta -acétoxy-7,17-dione, (8) DELTA 5-androstène-3 beta ,7 alpha ,17 beta -triol-16-one, (9) DELTA 5-androstène-3 beta ,17 beta -diol-7,16-dione, (10) DELTA 5-androstène-3 beta ,16 alpha ,17 beta -triol-7-one et leurs dérivés, dans lesquels un ou plusieurs des substitutants hydroxyle ou céto constituent un groupe convertible en ceux-ci par hydrolyse.
Lardy Henry A.
Reich Ieva L.
Yong Wei
Humanetics Corporation
Ridout & Maybee Llp
LandOfFree
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