Method of inhibiting remnant lipoprotein production

Details Method of inhibiting remnant lipoprotein production Method of inhibiting remnant lipoprotein production

A - Human Necessities

61

K

A61K 31/137 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) A61K 31/167 (2006.01) A61K 31/27 (2006.01) A61K 31/41 (2006.01) A61K 31/4196 (2006.01) A61K 31/47 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2554982

The present invention aims to provide for the treatment of hyperlipidemia, arteriosclerosis and hyper-remnant-emia, and to inhibit remnant lipoportein production by adminsetering an inhibitor of CEPT (cholesteryl ester transfer protein). Said inhibitor is a compound selected from the group cosisting of compounds of formula I to fomula XXIII, and compounds selected from the group consisting of JTT-705, CP-529414, SC-795, SC-744, SC-554, SC-71952, SC-56960, SC-57201, PD-140195, WK-5341A, WK-5344B, CETI-1 (CETP Vaccine), BM99-1 and BM99-2.

L'objectif de la présente invention est de fournir un procédé pour inhiber la production de lipoprotéines restantes et un inhibiteur de production de lipoprotéines restantes, lequel procédé consiste à administrer un composé possédant une activité inhibitrice de la CETP à un sujet. L'inhibiteur de production de lipoprotéines restantes selon la présente invention contient comme principe actif un composé possédant une activité inhibitrice de la CETP.

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